①How long is the incubation period?
Within 3 months: 80-90%;
Six months-1 year: 4%-10%;
Over 1 year: 1%;
WHO: The longest on record should be 6 years.
②Why have you been lurking for so long?
Because the virus has a strong affinity for nerve tissue.
Process: RV (a representative species of rabies virus) invades → breeds for 4 to 6 days → invades nearby nerves first → spreads to the central nervous system (invades the brain) → starts to attack various organs after winning the headquarters → GG
Note: The number of viruses entering the human body is different, the first processing method is different, the individual resistance is different, and the distance between the scratched and bitten site from the head and neck will affect the time of latent onset.
③Pathogenesis
RV utilizes glycoproteins to bind to nerve-specific receptors, affecting the inhibition of maintenance Synthesis of proteins required for neural function, ultimately resulting in neurological disorders.
RV glycoprotein (G protein) and matrix protein (M protein) can induce apoptosis.
RVs can not only evade the pursuit of immune troops, but also allow them to get out of their way, and then take advantage of the fire.
④That’s why there are these symptoms
mania, anxiety, fear of wind, fear of water, salivation, pharyngeal muscle spasm, mental disorder, paralysis.
Conclusion:
Rabies is preventable but not treatable.
As long as the skin is damaged, the virus may enter, and injection is recommended.
Judgment of damage: When wiping with iodophor alcohol, if there is a pain reaction, it is likely to be damaged, but it is invisible to the naked eye.
Q: My cat has been vaccinated against rabies, should I still use the vaccine?
A: Vaccination does not mean that there are antibodies in the body at this moment; having antibodies does not mean that there is no virus at this moment.